Hormones treatment getting transgender women is meant to feminize people of the modifying weight shipments, inducing nipple development, and you may cutting male development growth positive singles ücretsizdir of hair (11). Estrogens will be pillar procedures to own trans girls people. Using a negative feedback loop, exogenous treatment inhibits gonadotropin hormonal regarding pituitary gland, resulting in a reduction in androgen manufacturing (12). Estrogen by yourself is usually lack of to achieve desirable androgen suppression, and you may adjunctive anti-androgenic treatment therapy is and usually expected.
Ethinyl estradiol had previously been the fresh pillar of estrogen-brought treatment. This can be no longer the outcome, since clinical proof have presented an effective matchmaking ranging from ethinyl estradiol and also the occurrence from strong venous thrombosis (13). This means that, you will find strong recommendations from the entry to ethinyl estradiol inside transgender customers (8). Dental (Estrace ® , Gynodiol ® ) and you can transdermal (Alora ® , Climera ® , Esclim ® , Estraderm ® , Vivelle ® ) estradiol and you can parenteral estradiol valerate (Delestrogen ® ) are currently widely known preparations of the hormone estrogen. Look for Table dos getting dosing recommendations. Zero research has looked at the efficacy of the many formulations certain so you’re able to transgender hormone administration. After the age of 40, transdermal formulations try necessary because they bypass earliest ticket metabolism and seem to be of best metabolic users (14).
Dining table dos
There are not any unanimous ideas for the use of anti-androgens. Options are in addition to listed in Table 2 . Spironolactone is one of the most prominent medications familiar with prevents endogenous testosterone in the trans girls patients. The most significant exposure with the spironolactone is actually hyperkalemia, hence are going to be closely monitored.
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